Eyeshield 21's Manga and Anime are broken into several story arcs. The following are the arc names, a description of the arc's plot and the chapters and episodes they comprise. Please note that some of the following arc names may not be canon.
- Spring Tournament Arc
- Rivalry Match Arc
- Death March Arc
- Autumn Tournament Arc
- Cream Puff Arc (anime only)
- Death Game Arc (anime only)
- Kanto Tournament Arc
- Christmas Bowl Arc
- Youth World Cup Arc